Key Takeaways
- 12 days = 4 Buenos Aires + 3 Mendoza + 4 Patagonia + 1 buffer/transit. Internal flights are essential — distances are too large to drive.
- Mendoza's Uco Valley is the high-end wine destination; Lujan de Cuyo is the accessible classic. Book wineries in advance.
- Perito Moreno Glacier is one of few advancing glaciers on earth. Calving every 30 minutes in warm weather. The boat trip to the face is worth the extra cost.
- El Chaltén is the trekking capital — Fitz Roy and Cerro Torre are among the world's most dramatic alpine peaks. Day trip from El Calafate.
Argentina is too big to see in one trip — the country is the eighth largest in the world, and the distance from Buenos Aires to El Calafate in Patagonia is roughly the same as New York to Las Vegas. But the three-region combination — Buenos Aires, the Mendoza wine country, and Patagonia's Lake District or southern ice fields — is what makes Argentina special, and a 12-day trip can capture all three with internal flights.
Days 1–4: Buenos Aires. Four days minimum. Buenos Aires is one of the great Latin American capitals — European architecture, exceptional food, the tango culture that defines it, and neighborhoods that each feel like their own city. Day one: gentle exploration of San Telmo (Sunday is the antique market day if it aligns), an asado dinner at a parrilla. Day two: Recoleta Cemetery (where Eva Perón is buried, with mausoleums that look like a small city), the MALBA contemporary art museum, and dinner in Palermo Soho or Palermo Hollywood. Day three: La Boca's Caminito (the colorful Italian immigrant neighborhood, touristy but visually distinctive), an afternoon at the Teatro Colón opera house tour, and a tango show at La Ventana or Café Tortoni. Day four: a Tigre delta day trip via train and boat — the network of canals just outside the city.
Day 5: Travel to Mendoza. Fly Buenos Aires to Mendoza (2 hours). Argentina's wine capital sits at the foot of the Andes and produces some of the best Malbecs in the world. Stay in Mendoza city or in the wine country itself (Vistalba, Chacras de Coria, or further out in the Uco Valley). The Uco Valley is the high-end wine destination; Maipu is the more accessible one for first-timers.
Days 6–7: Mendoza wine country. Two full days at the wineries. Day 6: visit 3–4 wineries in Maipu or Lujan de Cuyo — Bodega Catena Zapata, Achaval-Ferrer, Bodega Lagarde, and the boutique producers. Most wineries require advance booking for tastings. Day 7: drive into the Uco Valley for the high-altitude wineries — Andeluna, Domaine Bousquet, Salentein. The drives between wineries themselves are spectacular — Andean foothills, snow-capped peaks visible to the west. Lunch at a bodega is a real experience; many wineries have excellent restaurants integrated with the tasting tour.
Day 8: Travel to El Calafate. Fly Mendoza to El Calafate (3.5 hours direct, or via Buenos Aires depending on schedule). El Calafate is the gateway to the southern Patagonian ice fields and Glaciar Perito Moreno — one of the few advancing glaciers on earth. Arrive by lunch and spend the afternoon walking around the small town.
Days 9–10: Perito Moreno and El Chaltén. Day 9: a full-day trip to Perito Moreno Glacier — the boardwalks let you see the glacier face from multiple angles, and the calving (when ice breaks off) happens roughly every 30 minutes during warm weather. The boat trips up to the face are worth the extra cost. Day 10: drive 3 hours north to El Chaltén (the trekking capital of Argentina, at the base of Mount Fitz Roy and Cerro Torre) for one of the most spectacular alpine landscapes anywhere. Stay overnight in El Chaltén and hike either to the Laguna de los Tres viewpoint (8 hours, demanding) or the easier Laguna Capri.
Day 11: Return travel. Drive from El Chaltén back to El Calafate, fly to Buenos Aires. Spend the evening in BA for a final asado dinner and a night out in Palermo.
Day 12: International departure. Most international flights leave Buenos Aires in the evening; use the day for a final brunch, the San Telmo Sunday market if it's a Sunday, or one of the museums you didn't reach earlier.
Practical notes: Argentina has had ongoing currency volatility for years. Use Western Union to convert dollars to pesos at the official rate, which often beats credit card exchange rates. Cash is common for many small purchases; keep small dollar bills as a backup. Tipping: 10% at restaurants, $10–15 per person per day for guides on full-day excursions. The dry season for Patagonia is summer (December–February), but it's also peak tourist season. October–November and March–April are shoulder seasons with lower prices and fewer crowds. Tango is real and worth seeing live — La Ventana is the polished tourist version, Café Tortoni is the historic version, Bar Sur is the more authentic small-venue option.
Frequently Asked Questions
Should I drive or fly between regions in Argentina?
When is the best time to visit Patagonia?
How much should I budget for Argentina with the currency situation?
Sources
- UNESCO World Heritage Centre – Los Glaciares National Park(accessed 2026-01-01)
- Argentina Tourism – Official Site(accessed 2026-01-01)
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